Immediately after the pitcher releases the ball, press Start. You will see where the ball is going and if it will be a strike or ball. Resume the game and move your batting cursor over it to get a nice powerful swing. This will help you improve your hitting. Note: You do not need to press Start directly after he lets go of the ball -- it just gives you more time to move your cursor after the game is resumed.
Use the pause technique before batting. When you see where the ball is going, try your best to get the ball as close to the point of the contact triangle (the part closest to the batter, not the thick part of the triangle). you will usually get homeruns or at least doubles.
Cheat Menu
Press L at the controller selection screen to activate cheats that have been bought.
Control Homerun Replay
After hitting a homerun, a replay of it will be displayed. When you see your batter heading home from third base, press various buttons to see different angles.
Easy Cards
Use the following trick to unlock all the cards in one or two games. Once you unlock the Cooperstown Legends and the Pixels, play as the Legends. You will find that within the fifth or sixth inning, every hit equals ten points and possibly more. Constantly hit homeruns and strike out the batters and you should have forty to fifty packs to open after the game. This is the easiest way to complete your card collection and unlock the cheats.
Easy Points
You can gain "points" for certain feats performed during a game. An easy way to get a lot of points is to throw a perfect game. This is worth 100 points. Switch controls every time the CPU is up at bat and intentionally strike out. This will get you points for 27 strikeouts, and for a perfect game. Repeat as many times as needed.
To get more points in franchise mode to sign your free agents, during the off season either create a player and pick him up as a free agent or sign free agents and release them at the end of the season.
Hear Thom Brennaman's Stories
Start a game and allow the controller to remain idle. A few minutes after the lineups and the starting pitcher are announced, Thom Brennaman will start telling in-depth stories about baseball.
Restore Pitcher's Energy
In season, franchise or expansion mode, go to the DL, and put any pitcher on the 15 day DL. Then immediately take him back into your lineup. He will have recovered all his energy.